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Debate: Transfer of Mosaics

Moderator: Micah Hill, DO
Pro:
Eric Forman, PhD; Barry Behr, MD
Con: Lauri Black, CGC; Alex Quaas, PhD

Saturday, May 8
2:15 PM - 3:00 PM

Session Description:

With the advent of widespread use of pre-implantation genetic testing for aneuploidy (PGT-A), the complexity of the practice of assisted reproductive technology (ART) has increased. In addition to “euploid” and “aneuploid” testing results after trophectoderm biopsy, the finding of (low or high) “mosaic aneuploidy” may be encountered on PGT-A testing reports. When a patient has no euploid embryos, and the only embryo(s) available for transfer are reported as mosaic, a complex decision has to be made whether to proceed with mosaic embryo transfer (MET) or to initiate another cycle with the goal of generating euploid embryos for transfer.

This lecture / activity is intended to review the background on this complex topic from a scientific, clinical and genetic counseling perspective, and to expose fertility providers to the wide array of arguments in favor and against MET.

At the conclusion of the activity, participants will feel more confident in their ability to adequately counsel patients faced with the decision whether to proceed with the transfer of an embryo reported as mosaic, or not.

Learning Objectives:

  1. Describe the scientific and clinical background regarding a test result of mosaicism on pre-implantation genetic testing (PGT-A).
  2. Identify scientific evidence and clinical data in favor of the transfer of mosaic embryos
  3. Outline concerns regarding the transfer of mosaic embryos, and provide arguments why fertility providers should refrain from transferring mosaic embryos in clinical practice.

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