Igenomix Product Theater Embryonic Cell Free DNA Analysis in Spent Culture Media: Test Reliability and Clinical ApplicationsJuliana Cuzzi, PhDThursday, March 26 Session Description: The high incidence of aneuploid embryos in IVF (ranging from 20% to 100%) is an important biologic burden. Preimplantation genetic testing for aneuploidy (PGTA) is, at present, the most reliable method to assess the chromosomal status of preimplantation embryos. Currently, DNA isolated and amplified from trophectoderm (TE) biopsies and analyzed by means of next-generation sequencing (NGS) is the state of the art for this technique. Despite the value of PGT-A, there are two main unsolved problems causing controversies in the scientific community. First, embryo biopsy requires specialized equipment and expertly trained operators to maintain protocols to protect embryo viability. However, possible harm to the embryo is always a concern of both doctors and patients... Continue Reading the DescriptionSession Objectives: According to the exposed above, the general learning objectives of this session is to elucidate to the audience what is non-invasive preimplantation genetic test, what is already described on scientific literature and what are still under research. The specific objective is to present how Igenomix has been approaching this innovative technology, what we have learned after two articles published and one RCT study on going and how could this new diagnostic strategy changes the IVF centers routine either their clinical perspective of the preimplantation genetic chromosome screening and embryo selection. |
68th Annual Meeting